| 硝苯柳胺的合成 |
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| 引用本文： | 易健民,施天益,张一甫,成本诚.硝苯柳胺的合成[J].中南大学学报(自然科学版),1999(5). |
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| 作者姓名： | 易健民 施天益 张一甫 成本诚 |
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| 作者单位： | 岳阳大学化学工程系!，岳阳，414000，岳阳大学化学工程系!，岳阳，414000，岳阳大学化学工程系!，岳阳，414000，中南工业大学化学系 |
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| 摘 要： | 以水杨酸、次氯酸叔丁酯和对硝基苯胺为原料分２ 步合成了硝苯柳胺．第１ 步用次氯酸叔丁酯和水杨酸反应合成５氯水杨酸；第２ 步用５氯水杨酸、二氯亚砜和对硝基苯胺反应合成硝苯柳胺．第１ 步是一种区域专一性反应，杂质极少，从而使第２ 步反应产物易于提纯．此外，用紫外光谱、红外光谱和核磁共振谱对硝苯柳胺的结构进行了表征．结果表明，产品纯度高达９７－９％ ，且其收率也可达８１ ％ ．
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| 关 键 词： | 硝苯柳胺 次氯酸叔丁酯 水杨酸 合成 |
SYNTHESIS OF NIPHENSAMIDE |
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| Yi Jianming,Shi Tianyi,Zhang Yifu,Cheng Bencheng.SYNTHESIS OF NIPHENSAMIDE[J].Journal of Central South University:Science and Technology,1999(5). |
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| Authors: | Yi Jianming Shi Tianyi Zhang Yifu Cheng Bencheng |
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| Abstract: | Niphensamide is synthesized from salicylic acid, t butyl hypochlorite and 4 nitroaniline et al by two steps. In the first step, 5 chloroalicylic acid is synthesized by salicylic acid with t butyl hypochlorite. In the second step, Niphensamide is synthesized by 5 chlorosalicylic acid, thionyl chloride and 4 nitroaniline. The first step is a regiospecific reaction with less impurity, so the product prepared in the second step was purified easily. The results show that the purity of the product is 97 9%, and the yield of the product is 81%. Through the spectrograms of UV, IR, NMR and elementary analysis of the product, the constitutional formula of it is proved to be niphensamide. |
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| Keywords: | niphensamide t butyl hypochlorite salicylic acid synthesis |
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