Die Wirkung der Lipoid- und Polysaccharid-Komponente endotoxischer Lipopolysaccharide gram-negativer Bakterien auf die Leukozytenkultur

Summary Highly purified lipopolysaccharides derived from gramnegative bacteria (endotoxins) stimulate the migration of leucocytes from cultures of chick leucocytes. This effect, as well as many endotoxic manifestations of the preparationsin vivo (pyrogenicity, toxicity, etc.), is induced by their lipid fraction (lipid A), while the respective species-specific polysaccharide functions as lyophilizing carrier which, fundamentally, can be substituted by other inert carriers (e.g. protein).