Myelin changes in the rats CNS following intraventricular injection of serum

Summary Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.Acknowledgments. The authors thank J. Mellach and P. Salinas for their skillful technical assistance. The study was supported by the Danish Multiple Sclerosis Society.