Solubilization and characterization of a ouabain-sensitive protein from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) in cat cardiac muscle |
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| Authors: | S Fujino K Satoh T Bando T Kurokawa T Nakai K Takashima M Fujino |
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| Affiliation: | Department of Pharmacology, Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan. |
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| Abstract: | A new glycoprotein of 31,500 dalton, which has a high affinity for ouabain, and is independent of (Na+-K+)-ATPase, was solubilized from transverse tubule membrane and junctional sarcoplasmic reticulum complexes (TTM-JSR) of cat cardiac muscle. This protein could be extracted only in small amounts from sarcolemma-plasma membrane (SLM-PL) fragments, suggesting that it indeed originates from the TTM-JSR. |
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