Chemoelectrical signal transduction in olfactory sensory neurons of air-breathing vertebrates |
| |
Authors: | S. Frings |
| |
Affiliation: | (1) Institut für Biologische Informationverarbeitung 1, Forschungszentrum Jülich, 52425 Jülich (Germany), Fax: +49 2461 61 4216, e-mail: s.frings@fz-juelich.de, DE |
| |
Abstract: | When odorants bind to the sensory cilia of olfactory sensory neurons, the cells respond with an electrical output signal, typically a short train of action potentials. This review describes the present state of knowledge about the olfactory signal transduction process. In the last decade, a set of transduction molecules has been identified which help to explain many aspects of the sensory response. Odor-induced second-messenger production, activation of transduction channels, the central role of the ciliary Ca2+ concentration, as well as mechanisms that mediate adaptation, are all qualitatively understood on the basis of a consistent scheme for chemoelectrical transduction. This scheme, although necessarily incomplete, can serve as a working model for further experimentation which may reveal kinetical aspects of signal transduction processes in olfactory sensory neurons. |
| |
Keywords: | . Olfaction chemoreception sensory physiology signal transduction receptor current cyclic nucleotide-gated channel chloride channel. |
本文献已被 PubMed SpringerLink 等数据库收录! |
|