Effects of a bovine pineal peptidic fraction (E5) on plasma and pituitary levels of LH,FSH and prolactin |
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| Authors: | Mary K Vaughan B A Richardson L Y Johnson R J Reiter P Pevet C Neascu |
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| Institution: | (1) Department of Anatomy, The University of Texas Health Science Center at San Antonio, 78284 San Antonio, Texas, USA;(2) The Netherlands Institute for Brain Research, Amsterdam, (The Netherlands);(3) Oncological Institute, Bucharest, (Romania);(4) Present address: The Netherlands Institute for Brain Research, Amsterdam, The Netherlands;(5) Present address: Oncological Institute, Bucharest, Romania |
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| Abstract: | Summary Pituitary levels of prolactin were significantly diminished after 5 s.c. injections spaced 12 h apart of 5  g of a partially purified bovine pineal peptide fraction (E5) in both intact and castrated rats. E5 treatment did not significantly affect the castration-induced changes in plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH) or pituitary LH but did partially block the pituitary fall in FSH in castrated animals.Supported by NSF grant PCM 8003441 and NIH Center for Reproductive Biology (Bioassay Core) No.P30 HD 10202. Many thanks are due A. Moreno for his excellent technical assistance. |
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