Normal osteoclast number and function in rat pups lacking parathyroid hormone |
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| Authors: | M Krukowski A J Kahn |
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| Institution: | (1) Department of Biology, Washington University, 63130 St. Louis, MO, USA;(2) Division of Bone and Mineral Metabolism, School of Dental Medicine, Washington University, 63110 St. Louis, MO, USA |
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| Abstract: | Summary In parathyroidectomized suckling rats, bone modeling and the number and activity of cells in the osteoclast population are normal. These findings are at variance with observations in older animals and suggest that factors other than parathyroid hormone influence osteoclast formation and function in the neonate.This work was supported by grants HD-07419 and DE-04629 from the NIH. We thank Darrell Iler for his excellent technical assistance. |
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