The role of thrombospondin-1 in apoptosis |
| |
| Authors: | Friedl P Vischer P Freyberg M A |
| |
| Institution: | (1) Technical University of Darmstadt, Inst. Biochem., Petersenstr. 22, 64827 Darmstadt (Germany), DE;(2) University of Münster, Inst. Arterioskleroseforschung, Domagstr. 3, 48149 Münster (Germany), DE;(3) CytoTools GmbH, Petersenstr. 22, 64827 Darmstadt (Germany), Fax + 496151166025, e-mail: freyberg@cytotools.de , DE |
| |
| Abstract: | The thrombospondins are a family of extracellular proteins that participate in cell-to-cell and cell-to-matrix communication.
They regulate cellular phenotype during tissue genesis and repair. Five family members, each representing a separate gene
product, probably exist in most vertebrate species. Like most extracellular proteins, the thrombospondins are composed of
several structural domains that are responsible for the numerous biological functions that have been described for this protein
family. Considerable progress has been made towards understanding the function of thrombospondins. The role of thrombospondin
in the process of apoptosis or programmed cell death has recently come into focus. In this review we will concentrate on the
role of thrombospondin-1 in the broad field of apoptotis research.
Received 5 December 2001; received after revision 28 March 2002; accepted 28 March 2002 |
| |
| Keywords: | , Thrombospondin, apoptosis, integrin, CD36, CD47, |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
