A型肉毒杆菌毒素治疗面肌痉挛、脸肌痉挛68例报告

目的：探讨A型肉毒杆菌毒素治疗面肌痉挛和睑肌痉挛的效果，方法：应用A型肉毒杆菌毒素局部肌肉注射治疗共68例，药物浓度为0．1－0．2ng/mL(25-50U/mL),结果：有效率为100％，其中完全缓解85．3％，明显缓解及部分缓解14．7％，显效时间4h-3d，作用持续时间12－30周，无过敏和全身中毒反应，局部副作用轻微，可逆，结论：A型肉毒杆菌毒素治疗面肌痉挛和脸肌痉挛安全，简便，有效，可作为治疗面肌痉挛和睑肌痉挛的首选药物。

Treatment of hemifacial spasm and blepharospasm with botudinum toxin A: clinical report of 68 cases

Aim: To evaluate the efficacy of Botulinum toxin A for hemifacial spasm and for the facialspasm and blepharospasm. Methods: a total of 68 individuals were enrolled in the clinical study. TheBotulinum Toxin A was locally injected into the involved muscles. The dosage for each injection was 1～2 ng/mL(2.5～50 U/mL). Results: The overall successful rate of relief of spasm was 100%. Amongthem, 85.3% of patients had excellent improvement on the spasm intensity scale, while the rest 14.7%of patients had moderate improvement. The beneficial effect began at the 4 h to 3days after the injection,and the duration of beneficial effects was 12～30 weeks. Only local side effects appeared in some pa-tients, but it was mild and reversible. Conclusion: Botulinum toxin A injection is an effective, safe andsimple therapeutic method for patients with hemifacial spasm and blepharospasm, and may be consideredas the first choice for the treatment of patients with hemifacial spasm and blepharospasm.