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Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila
Authors:Q Yu  H V Colot  C P Kyriacou  J C Hall  M Rosbash
Abstract:The period gene of Drosophila melanogaster, implicated in the control of both the circadian and male courtship song rhythms, is found to be polymorphic. Alleles differ in the length of a region of the gene encoding a series of threonine-glycine repeat units. The phenotypes of transformed fruit flies, in which the only functional period gene lacks the entire perfect threonine-glycine repeat region, show that the effects of the period gene on the circadian and male courtship song rhythms can be dissociated.
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