| HPP对Cl_4致大鼠肝脏灌流损伤的影响 |
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| 引用本文： | 蒲含林,洪岸,彭波,蒋建敏,许实波. HPP对Cl_4致大鼠肝脏灌流损伤的影响[J]. 中山大学学报(自然科学版), 2001, 0(5) |
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| 作者姓名： | 蒲含林 洪岸 彭波 蒋建敏 许实波 |
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| 作者单位： | 暨南大学生物工程研究所 广东 广州 510632(蒲含林，洪岸)，中山大学生命科学学院 广东广州510275(彭波，蒋建敏)，中山大学生命科学学院 广东广州510275(许实波) |
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| 摘 要： | 对离体大鼠肝脏进行灌流，用ＣＣｌ４造成肝细胞损伤，观察了２－乙基－３－羟基－６－苯硫基－４（１Ｈ）－吡啶酮（ＨＰＰ）对 ＣＣｌ４诱发的大鼠肝脏灌流损伤的影响，结果表明 ＨＰＰ对 ＣＣｌ４引发的肝细胞损伤导致丙氨酸转氨酶（ＡＬＴ）、天门冬氨酸转氨酶（ＡＳＴ）、乳酸脱氢酶（ＬＤＨ）的升高有明显的抑制作用．提示 ＨＰＰ对离体大鼠肝脏的损伤有抑制作用．
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| 关 键 词： | 2-乙基-3-羟基6-苯硫基-4(1H)、吡啶酮 CCl4 肝脏灌流 损伤 |
Effect of 2-Ethyl-3-Hydroxy-6-Phenylthio-4- (1H) -Pyridinone on Perfused Rat Liver Injury Induced by Carbon Tetrachloride |
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| PU Han-lin,HONG An,PENG Bo,JIANG Jian-min,XU Shi-bo. Effect of 2-Ethyl-3-Hydroxy-6-Phenylthio-4- (1H) -Pyridinone on Perfused Rat Liver Injury Induced by Carbon Tetrachloride[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2001, 0(5) |
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| Authors: | PU Han-lin HONG An PENG Bo JIANG Jian-min XU Shi-bo |
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| Abstract: | This paper reported the effects of 2-ethyl-3-hydroxy-6.-phenylthio-4- (1H) -pyridinone (HPP) on per- fused rat liver injury induced by carbon tetrachloride. The results showed that HPP obviously reduced the release of alanine aminotransferase, aspartic aminotransferase and lactic dehydrogenase from carbon tetrachloride induced hep- atocytes. It indicated that HPP has a hepatoprotective action on isolated liver injury. |
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| Keywords: | ethyl-3-hydroxy-6-phenylthio-4- (1 H) -pyridinone carbon tetrachloride liver injury |
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