Effect of taurine on mitogen response of human lymphocytes |
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Authors: | Herminia Pasantes-Morales J M León-Cázares |
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Institution: | (1) Centro de Investigaciones en Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-600, México 20, D. F., (Mexico) |
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Abstract: | Summary Taurine selectively inhibits the phytohemagglutinin-stimulated incorporation of3H-thymidine by human cultured lymphocytes (50% inhibition by 12.5 mM taurine). Decreasing effects of taurine on Na–K ATPase activity or on calcium accumulation by lymphocytes might be responsible for its action on cell proliferation.Thanks are due to Mr F. Cervantes Salas for technical assistance. This work was partly supported by grants. No. 5 RO1-EY 02540-02 from the National Eye Institute and No. PCCBNAL 790219 from CONACyT. |
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