| Total Synthesis of Securinega Alkaloids |
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| 引用本文： | T. Honda. Total Synthesis of Securinega Alkaloids[J]. 复旦学报(自然科学版), 2005, 44(5): 779-780 |
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| 作者姓名： | T. Honda |
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| 作者单位： | Faculty of Pharmaceutical Sciences, Hoshi Unizersity , Ebara 2-4-41 , Shinagawa-ku. Tokyo 142-8501, Japan |
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| 摘 要： | Naturally occurring Securinega alkaloids （1-4） （Fig. 1）, with their wide range of structural and stereochemical features, continue to provide challenging synthetic targets, since these alkaloids exhibit attractive biological activities. Securinine （1）, isolated from Securinega suffruticosa , was structurally determined to contain an indolizidine skeleton with an azabicyclo octane system together with an α,β-unsaturated γ-1actone ring.This alkaloid has been clinically used in Russia as a CNS stimulating drug, and has been shown to act as a stereospecific antagonist at the GABA binding site of the GABAA-receptor complex.
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| 关 键 词： | 生物碱 一叶萩碱 Diels-Alder反作用 生物活性 |
| 文章编号： | 0427-7104（2005）05-0779-02 |
| 收稿时间： | 2005-08-05 |
| 修稿时间： | 2005-08-05 |
Total Synthesis of Securinega Alkaloids |
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| T. Honda. Total Synthesis of Securinega Alkaloids[J]. Journal of Fudan University(Natural Science), 2005, 44(5): 779-780 |
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| Authors: | T. Honda |
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| Abstract: | |
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| Keywords: | Securinega alkaloid securinine viroallosecurinine ring closing metathesis Diels-Alder reaction |
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