Magnesium enhances human pancreatic elastase digestion of125I-labeled elastin |
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| Authors: | M Rabaud F Lefebvre P V Graves C Desgranges H Bricaud |
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| Institution: | (1) Unité de recherches de Cardiologie U8, INSERM, avenue du Haut-Lévêque, F-33600 Pessac, (France);(2) Institut de Biochimie Cellulaire et Neurochimie, 1, rue Camille Saint-Saëns, F-3300 Bordeaux, (France) |
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| Abstract: | Summary The effect of some divalent cations, especially Mg++, on elastinolysis by porcine or human pancreatic elastase has been determined using125Iodine-labeled elastin as substrate. Elastin degradation was significantly increased in the presence of 10–3 M Mg++. If elastin was pre-incubated with 0.5 (w/v) Triton, there was a further increase in elastinolysis to 2.6 times the original rate. |
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| Keywords: | Porcine and human pancreatic elastase elastin Triton-Mg++ |
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