| 3-溴代香豆素二甲双胍类化合物的合成 |
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| 引用本文： | 祁刚,屠树滋. 3-溴代香豆素二甲双胍类化合物的合成[J]. 盐城工学院学报(自然科学版), 2006, 19(1): 8-10 |
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| 作者姓名： | 祁刚 屠树滋 |
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| 作者单位： | 1. 盐城工学院,科技处,江苏,盐城,224003
2. 中国药科大学,药物化学教研室,江苏,南京,210009 |
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| 摘 要： | 运用拼合原理将常用降糖药物二甲双胍与有降糖活性的香豆素拼合，并根据前期的构效关系研究结果，设计了溴取代香豆素二甲双胍类化合物，合成方法是以香豆素为原料。分别经溴加成、脱溴化氢、氯磺化、缩合四步反应得到了两个新的3-溴代香豆素二甲双胍类化合物，该类化合物未见文献报道，结构均经IR、^1HNMR、MS鉴定。
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| 关 键 词： | 3-溴代香豆素二甲双胍 香豆素 二甲双胍 |
| 文章编号： | 1671-5322（2006）01-0008-03 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2005-12-19 |
The Synthesis of 3-brominecoumarin-dimethylbiguanid |
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| QI Gang,TU Shu-zi. The Synthesis of 3-brominecoumarin-dimethylbiguanid[J]. Journal of Yancheng Institute of Technology(Natural Science Edition), 2006, 19(1): 8-10 |
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| Authors: | QI Gang TU Shu-zi |
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| Affiliation: | 1.Department of Technology,Yancheng Institute of Technology,Jiangsu Yancheng 224003,China;2.Department of Medicinal Chemistry,China Pharmaceutical University,Jiangsu Nanjing 210009,China |
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| Abstract: | On the basis of primary study of structure- activity relationship, bromine substituted coumarin -dimethylbiguanid was designed by matching principle treated with coumarin and dimcthylbiguanid. Two new compounds were synthesised by four steps of reaction. There are addition, elimination, sulfochlorination and condensation. Target structures were identified by IR, 1 H - NMR and MS spectra never reported. |
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| Keywords: | 3 - brominecoumarin - dimethylbiguanid coumarin dimethylbiguanid synthesis |
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