| 环胞苷二棕榈酸酯脂质体抗癌活性及化学稳定性的研究 |
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| 引用本文： | 王继波,李珊.环胞苷二棕榈酸酯脂质体抗癌活性及化学稳定性的研究[J].青岛大学学报(自然科学版),1999,12(4):85-89. |
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| 作者姓名： | 王继波 李珊 |
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| 作者单位： | 青岛大学医学院化学教研室!青岛，266021，青岛大学医学院化学教研室!青岛，266021 |
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| 摘 要： | 3＇，5＇—环胞苷二棕榈酸酯是环胞苷的前体药物，它在体内水缺脱氨生成其相应的尿嘧啶衍生物，将脂质体作为3＇，5＇—环胞苷二棕榈酸酯的载体，与游离药物比较它们的抗癌活性及化学稳定性，结果显示，脂质体提高了药物的抗癌活性，改善了药物吸收，有效期延长3倍。
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| 关 键 词： | 3＇5＇—环胞苷二棕榈酸酯 脂质体 抗癌活性 化学稳定性 |
STUDIES ON ANTITUMOR ACTIVITY AND CHEMICAL STABILITYOF DIPALMITOYL CYCLOCYTIDINE IN LIPOSOME |
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| WANG Ji-bo, LI Shan.STUDIES ON ANTITUMOR ACTIVITY AND CHEMICAL STABILITYOF DIPALMITOYL CYCLOCYTIDINE IN LIPOSOME[J].Journal of Qingdao University(Natural Science Edition),1999,12(4):85-89. |
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| Authors: | WANG Ji-bo LI Shan |
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| Abstract: | 3',5'-Dipalmitoyl cyclocytidine(DPC), the prodrug of cyclocytidine, is known tounderso hydrolytic deamination in vivo to yield the corresponding uracil derivatives. Withliposome as a carrier of DPC, the anitUInor activity and chemical stability were comparedbetween DPC in liposome and DPC in aqueous solution. Results showed that liposomeimproved the anitumor activity and uptak of encapsulated prodrug. The shelflife of DPC inliposome was about 3 times higher than tha of free DPC |
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| Keywords: | 3' 5-Dipalmitotyl cyclocytidine(DPC) Liposome Antitumor activity Chemical stability |
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