基于密码子使用模式的冠状病毒亲缘关系分析

重症急性呼吸综合症(severe acute respiratorysyndrome,SARS),临床表现为非典型肺炎.由于SARS具有很高的传染性和一种新型的冠状病毒(SARS-CoV)被认为是引起SARS的病原体.SARS冠状病毒(SARS-CoV)属于巢状病毒目(OrderN idovirales),冠状病毒科(Fam ily Coronaviri-dae),冠状病

Coronaviruses phylogeny analysis based on the codon usage rates

SARS-CoV is a novel coronavirus,which has been identified as the cause of the outbreak of severe acute respiratory syndrome(SARS).In this paper,we presented a new approach based on the codon usage rates to analyze the phylogenetic relateion of coronaviruses.We made use of the codon usage rates derived from coronavirus RdRp genes to represent the virus,and with this method figured out the revolutionary distance of every two coronaviruses.With codon usage rates derived from all coding sequences of coronavirus to represent a genome,we also analyzed the relateion between SARS-CoVs and SARS-CoV-likes,which we from different hosts and different periods.The two results were both available,which not only reflected the relatedness of SARS-CoV and other coronaviruses but also opened out the revolution process of SARS-CoVs.