Proteolysis, proteasomes and antigen presentation. |
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| Authors: | A L Goldberg K L Rock |
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| Institution: | Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts. |
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| Abstract: | Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses. |
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