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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes |
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| Authors: | A Ullrich J R Bell E Y Chen R Herrera L M Petruzzelli T J Dull A Gray L Coussens Y C Liao M Tsubokawa |
| Abstract: | We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products. |
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