Relationship of ornithine decarboxylase activity to HCG induced androgen production by rabbit testis |
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| Authors: | E. V. YoungLai |
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| Affiliation: | (1) Department of Obstetrics and Gynecology, McMaster University, Faculty of Health Sciences, 1200 Main St. West, L8N 3Z5 Hamilton, Ontario, Canada |
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| Abstract: | Summary In the rabbit testicular ornithine decarboxylase activity and androgen content as well as serum androgens were increased 4 h after the injection of HCG. D,L-a-difluoromethylornithine (a-DFMO) alone or together with HCG inhibited enzyme activity although testicular and serum androgens were significantly increased aftera-DFMO and HCG. These data suggest that ODC activity is not required for testicular androgen production.This work was supported by the Medical Research Council of Canada, MT 4192. |
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