Purification from human plasma of endogenous dodium transport inhibitor(s) |
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Authors: | J. -F. Cloix G. Dagher M. Crabos M. -G. Pernollet P. Meyer |
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Affiliation: | (1) Department of Pharmacology, INSERM U7, and U90, Hôpital Necker, 161, rue de Sèvres, F-75015 Paris, (France) |
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Abstract: | Summary Na+, K+-ATPase inhibitors extracted from plasma of healthy human subjects displaced3H-ouabain binding to human erythrocytes and inhibited the Na+ efflux catalyzed by the Na+, K+-pump and unexpectedly the Na+, K+-cotransport system without alteration of the Na+, Na+-exchange or the Na+ passive permeability. This suggests the presence in healthy human plasma of endogenous factors with ouabain-like and furosemide-like activities.Acknowledgments. We are indebted to Dr M. A. Devynck for her advice on chemical measurements and to Dr R. P. Garay for his help with flux measurements |
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Keywords: | Plasma, human erythrocytes Na+-transport ouabain Na+K+-pump NaK-ATPase inhibitors |
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