| ITAM两步磷酸化基础上的TCR识别模型 |
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| 引用本文： | 张伟,漆安慎. ITAM两步磷酸化基础上的TCR识别模型[J]. 北京师范大学学报(自然科学版), 2003, 39(5): 640-644 |
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| 作者姓名： | 张伟 漆安慎 |
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| 作者单位： | 1. 北京师范大学管理学院系统科学系,100875,北京
2. 北京师范大学物理学系,100875,北京 |
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| 基金项目： | 国家自然科学基金;30070216; |
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| 摘 要： | 将T细胞受体(TCR)的活性与免疫酪氨酸受体激活基序(ITAM)活性联系起来，深入考虑了TCR与其配体的亲和力和离解率．结果表明抗原多肽上信号氨基酸部分的细小差别，将有效地引起截然不同的T细胞应答反应．发生在T细胞应答早期信号事件中的TCR与其配体的亲和力和离解率参与决定了最终的T细胞应答结果．
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| 关 键 词： | 免疫酪氨酸受体激活基序 T细胞受体 连续触发 亲和力 识别模型 细胞免疫应答 磷酸化 ITAM |
| 修稿时间： | 2003-03-25 |
TCR RECOGNITION MODEL DEPENDING ON THE TWO STEP ACTIVATION OF ITAM |
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| Zhang Wei ) Qi Anshen ). TCR RECOGNITION MODEL DEPENDING ON THE TWO STEP ACTIVATION OF ITAM[J]. Journal of Beijing Normal University(Natural Science), 2003, 39(5): 640-644 |
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| Authors: | Zhang Wei ) Qi Anshen ) |
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| Affiliation: | Zhang Wei 1) Qi Anshen 2) |
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| Abstract: | TCR ligands are complexes of peptides and MHC proteins on the surfaces of APCs. The interaction of antigen specific TCR with its antigenic ligand is important in immune system. And subtle change in the nature of the ligand turns out different T cell outcomes. The authors propose a quantitative model for the interaction of TCR and its ligand in T cell activation relying on the two step activation of ITAM. In this model, the affinity and dissociation rate of TCR with ligand play an important role in determining the outcome of T cell response and they work together to protect the accurate of the recognization. |
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| Keywords: | ITAM TCR serial triggering affinity |
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