| 室温离子液体催化阿司匹林的合成 |
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| 引用本文： | 谢辉,陈卓,母先誉,刘廉. 室温离子液体催化阿司匹林的合成[J]. 贵州师范大学学报(自然科学版), 2009, 27(1) |
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| 作者姓名： | 谢辉 陈卓 母先誉 刘廉 |
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| 作者单位： | 贵州师范大学,化学与材料科学学院,贵州,贵阳,550001;贵州师范大学,化学与材料科学学院,贵州,贵阳,550001;贵州师范大学,化学与材料科学学院,贵州,贵阳,550001;贵州师范大学,化学与材料科学学院,贵州,贵阳,550001 |
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| 基金项目： | 贵州师范大学校青年科学基金 |
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| 摘 要： | 研究了以几种1,3-二烷基咪唑离子液体为催化剂来合成阿司匹林的反应,考察了反应时间、酸醇摩尔比等对该反应的影响。结果表明:[BMIm]Br离子液体对阿司匹林的合成有较好的催化作用,最佳反应条件为:n水杨酸:n乙酸酐=1∶2,催化剂用量2mL,反应温度80~85℃,反应时间3h,收率可达81.6%。产物和离子液体不溶而分层,便于分离,且离子液体可以重复使用。
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| 关 键 词： | 室温离子液体 阿司匹林 催化合成 |
Catalytic synthesis of ionic liquids on aspirin at room temperature |
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| XIE Hui,CHEN Zhuo,MU Xian-yu,LIU Lian. Catalytic synthesis of ionic liquids on aspirin at room temperature[J]. Journal of Guizhou Normal University(Natural Sciences), 2009, 27(1) |
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| Authors: | XIE Hui CHEN Zhuo MU Xian-yu LIU Lian |
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| Affiliation: | School of Physics and Chemistry;Guizhou Normal University;Guiyang;Guizhou 550001;China |
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| Abstract: | The synthesis of aspirin was investigated in various ionic liquids 1,3-dialkylimidazolium.The effects of reaction time and ratio of acid to alcohol on the reaction were examined.Experimental results showed that ionic liquid Br could be used as a catalyst of aspirin.The optimized esterification conditions were: nsalicylic acid:nacetic anhydride=1∶2,catalyst 2mL,reaction temperature 80~85℃,reaction time 3h.The yield of esterification could reach 81.6%.The isolation of desired products could be achieved via simple decantation and ionic liquids could be reused. |
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| Keywords: | room temperature ionic liquids aspirin catalytic synthesis |
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