| 光热疗用GO-MoS2纳米载体的构建及应用 |
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| 引用本文： | 林谡轩,路伯庭,乐园.光热疗用GO-MoS2纳米载体的构建及应用[J].北京化工大学学报(自然科学版),2019,46(3):35-42. |
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| 作者姓名： | 林谡轩 路伯庭 乐园 |
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| 作者单位： | 北京化工大学 化学工程学院 有机无机复合材料国家重点实验室, 北京 100029 |
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| 基金项目： | 国家重大基础研究计划（2015CB932100） |
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| 摘 要： | 采用水热法在氧化石墨烯（GO）表面生长MoS2纳米片并枝接聚乙二醇（PEG）以改善其生物相容性。通过傅立叶变换红外光谱、透射电子显微镜等手段对GO-MoS2复合材料进行表征，利用酶标仪、荧光共聚焦显微镜等对复合物及载药复合物的细胞毒性及细胞摄入进行了探究。结果表明，所制备的纳米复合材料相比于GO表现出更高的药物负载率和释放率，以及显著的光热转换性能，具有应用于光热疗法的潜力。
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| 关 键 词： | 氧化石墨烯 GO-MoS2 光热疗法 纳米载体 |
| 收稿时间： | 2018-05-28 |
Construction and application of graphene oxide-MoS2 as a nanocarrier for photothermal therapy |
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| LIN SuXuan,LU BoTing,LE Yuan.Construction and application of graphene oxide-MoS2 as a nanocarrier for photothermal therapy[J].Journal of Beijing University of Chemical Technology,2019,46(3):35-42. |
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| Authors: | LIN SuXuan LU BoTing LE Yuan |
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| Institution: | State Key Laboratory of Organic-Inorganic Composites, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | MoS2 nanosheets were grown on a graphene oxide (GO) surface by a hydrothermal method and the resulting composite was grafted with polyethylene glycol (PEG) to improve its biocompatibility. The GO-MoS2 composite was characterized by FT-IR, TEM, and XPS. The cytotoxicity and cellular uptake of the composite and drug-loaded complex were investigated by using microplate readers and fluorescence confocal microscopy. The results show that the prepared composite nanomaterials have higher drug loading and release efficiencies than GO, as well as a promising photothermal conversion performance. The material therefore has the potential to be part of photothermal therapy. |
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| Keywords: | graphene oxide GO-MoS2" target="_blank">2')">GO-MoS2 photothermal therapy nanocarrier |
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