Participation of granulocytes and humoral factors in resolution of platelet aggregates during endotoxemia |
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| Authors: | R I Walker J R Fletcher D A Walden |
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| Institution: | (1) Experimental Hematology Department, Armed Forces Radiobiology Research Institute, and Department of Experimental Medicine, U.S. Naval Medical Research Institute, 20014 Bethesda, Maryland, USA |
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| Abstract: | Summary Hydrogen peroxide generated by phagocytizing granulocytes can prevent platelet aggregation induced by ADP or collagen but not by endotoxin. Endotoxin tolerance enhances granulocyte mobilization in response to endotoxin and reduces aggregation induced by endotoxin but not ADP or collagen. |
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