Rapid effects of insulin on cyclic GMP location in an intact protozoan. |
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| Authors: | L Kohidai J Barsony J Roth S J Marx |
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| Institution: | Metabolic Diseases Branch, NIDDK, Bethesda, Maryland 20892. |
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| Abstract: | We studied rapid changes in location of cyclic GMP in Tetrahymena pyriformis. Insulin caused cGMP localization in cilia and near the plasma membrane (0.5-1 min). Later (1-5 min) cGMP localization was diffuse in cytoplasm with perinuclear accentuation. Inactive insulin analogs did not elicit these changes. |
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