Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis |
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| Authors: | D Grunberger R Banerjee K Eisinger E M Oltz L Efros M Caldwell V Estevez K Nakanishi |
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| Institution: | Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032. |
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| Abstract: | The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE. |
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