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Identification of loci associated with schizophrenia by genome-wide association and follow-up |
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| Authors: | O'Donovan Michael C Craddock Nicholas Norton Nadine Williams Hywel Peirce Timothy Moskvina Valentina Nikolov Ivan Hamshere Marian Carroll Liam Georgieva Lyudmila Dwyer Sarah Holmans Peter Marchini Jonathan L Spencer Chris C A Howie Bryan Leung Hin-Tak Hartmann Annette M Möller Hans-Jürgen Morris Derek W Shi Yongyong Feng GuoYin Hoffmann Per Propping Peter Vasilescu Catalina Maier Wolfgang Rietschel Marcella Zammit Stanley Schumacher Johannes Quinn Emma M Schulze Thomas G Williams Nigel M Giegling Ina Iwata Nakao Ikeda Masashi Darvasi Ariel Shifman Sagiv He Lin Duan Jubao Sanders Alan R |
| Institution: | Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk |
| Abstract: | We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)). |
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