| 动脉粥样硬化模型小鼠血脂与血清胆红素关系的探讨 |
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| 引用本文： | 田枫,张阔,康爱君,周淑佩,郑振辉. 动脉粥样硬化模型小鼠血脂与血清胆红素关系的探讨[J]. 实验动物科学, 2007, 24(1): 13-15 |
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| 作者姓名： | 田枫 张阔 康爱君 周淑佩 郑振辉 |
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| 作者单位： | 北京大学医学部实验动物科学部,北京,100083 |
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| 摘 要： | 目的探讨动脉粥样硬化小鼠血脂与血清胆红素之间的关系。方法选取12月龄雄性动脉粥样硬化小鼠及同龄同性别正常对照C57BL/6J小鼠,分别测定血清甘油三酯、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白B水平、血清总胆红素、直接胆红素。结果动脉粥样硬化小鼠胆固醇、低密度脂蛋白、高密度脂蛋白、载脂蛋白B水平与同龄同性别的C57BL/6J小鼠相比极显著升高(P<0.01);动脉粥样硬化小鼠直接胆红素水平与C57BL/6J小鼠相比极显著降低(P<0.01)。结论动脉粥样硬化小鼠血脂与血清胆红素相关。
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| 关 键 词： | 动脉粥样硬化 血脂 胆红素 |
| 文章编号： | 1006-6179（2007）01-0013-03 |
| 收稿时间： | 2006-06-20 |
| 修稿时间： | 2006-06-20 |
Relationship Blood-Lipid to Serum Bilirubin in Apo E Gene-Knockout Mice |
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| TIAN Feng,ZHANG Kuo,KANG Ai-jun,ZHOU Shu-pei,ZHENG Zhen-hui. Relationship Blood-Lipid to Serum Bilirubin in Apo E Gene-Knockout Mice[J]. Laboratory Animal Science, 2007, 24(1): 13-15 |
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| Authors: | TIAN Feng ZHANG Kuo KANG Ai-jun ZHOU Shu-pei ZHENG Zhen-hui |
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| Affiliation: | Department of Laboratory Animal Sciences, Peking University Health Center, Beijing 100083, China |
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| Abstract: | Objective To delve into the relationship of blood-lipid to serum bilirubin in ApoE gene-knockout mice.Methods Male ApoE gene-knockout mice of twelve-month-old were selected in this study,and male C57BL/6J mice of twelve-month-old were used as controls.The levels of TG,TC,LDL-C,ApoB,T-BIL,and D-BIL in serum were determined in these mice.Results The serum levels of TG TC,LDL-C,ApoB in ApoE gene-knockout mice were significantly higher than those in C57BL/6J mice(P<0.01),and the serum level of D-BIL in ApoE gene-knockout mice was significantly lower than that in C57BL/6J mice(P<0.01).Conclusion Blood-lipid of the mice with atherosclerosis was correlated with serum bilirubin. |
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| Keywords: | Atherosclerosis Serum lipid Bilirubin Mice |
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