(1) Department of Genetics, University of Birmingham, POB 363, B15 2TT Birmingham, England;(2) Division of Developmental Biology, National Institute for Medical Research, Mill Hill, NW7 1AA London, (England)
Abstract:
Summary Axolotl forearms isolated from upper arm tissue either surgically or by local irradiation regenerate excessive structures after vitamin A treatment. This demonstration excludes the possibility of regeneration being altered by enhanced cellular migration and thus indicates that vitamin A respecifies cells close to the site of amputation.