Rosette formation by human T and B lymphocytes in the presence of adrenergic and cholinergic drugs |
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| Authors: | G G R Ferreira H K Massuda Brascher M Q Javierre W A Sassine A O Lima |
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| Institution: | (1) Division of Immunopathology, School of Medicine, U. F. R. J., Rio de Janeiro, (Brazil) |
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| Abstract: | Summary It was shown that adrenergic drugs, which increase the intracellular levels of cAMP, inhibit the rosette formation by T-lymphocytes, but stimulate the rosettes produced by B-lymphocytes. Cholinergic drugs, which increase the levels of cGMP, on the contrary, stimulate the formation of rosettes by T-lymphocytes but inhibit those produced by B-lymphocytes.Acknowledgments. This investigation was supported by Grant from National Council for Scientific and Technological Development (CNPq), Rio de Janeiro, Brazil. |
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