| 环丙氟哌酸的新法合成(英文) |
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| 引用本文： | 汪敦佳,张卫华,董镜华,郑静.环丙氟哌酸的新法合成(英文)[J].湖北师范学院学报(自然科学版),1998(3). |
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| 作者姓名： | 汪敦佳 张卫华 董镜华 郑静 |
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| 作者单位： | 湖北师范学院化学系 |
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| 摘 要： | 采用国内已有的诺氟沙星中间体7—氯—6—氟—4—羟基喹啉—3—羧酸乙酯为起始原料,首次以1—乙氧基—1—溴环丙烷为烷化剂,四丁基溴化胺为相转移催化剂,非质子极性溶剂为介质,在喹啉环上进行N—环丙基取代反应,再经两个工序得到了环丙氟哌酸,总收率达68.5％,该法合成路线短,收率高。
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| 关 键 词： | 环丙氟哌酸 合成 |
NOVEL SYNTHESIS OF CIPROFLOXACIN |
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| Wang Dunjia Zhang Weihua Dong Jinghua Zheng Jing.NOVEL SYNTHESIS OF CIPROFLOXACIN[J].Journal of Hubei Normal University(Natural Science),1998(3). |
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| Authors: | Wang Dunjia Zhang Weihua Dong Jinghua Zheng Jing |
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| Institution: | Department of Chemistry |
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| Abstract: | Ciprofloxacin was synthesized from the intermdeiate of Norfloxacin 6-fluoro-7-chloro-4-hydroxy-3-quinolinecarboxylic Acid ethyl Ester as the starting material via condensation with 1-bromo-l-ethoxycyclopropane followed by reductive elimination of ethoxyl group and then hydrolysis,condensation with piperazine in 68.5% overall yield. |
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| Keywords: | ciprofloxacin systhesis |
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