| 肺癌影像学表现与erbB－2、bcl－2表达相关性的初步观察 |
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| 引用本文： | 罗良平,张海伟,陈金城,王惠华.肺癌影像学表现与erbB－2、bcl－2表达相关性的初步观察[J].暨南大学学报,1996(4). |
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| 作者姓名： | 罗良平 张海伟 陈金城 王惠华 |
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| 作者单位： | 暨南大学医学院附属医院影像科 |
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| 摘 要： | 为了从基因水平探讨肺癌影像学表现的分子生物学基础，利用免疫组化技术及计算机图象系统测定手术病理证实之３３例肺癌标本中癌基因ｅｒｂＢ－２，ｂｃｌ－２的表达水平，系统分析其表达水平与影像学表现的相关性。结果显示肺癌的某些影像学征象如肿块大小、三级支气管受累、胸膜受侵及肺门纵隔淋巴结转移均与其癌基因ｅｒｂＢ－２、ｂｃｌ－２的表达水平密切相关，而且这两类基因的表达对其影像学征象的影响呈现相互抑制的关系
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| 关 键 词： | 肺癌 免疫组织化学 erbB－2基因 bcl－2基因 放射摄影术 电算体层成像 |
Preliminary Studies on Correlation of Image Characteristicsof Lung Carcinoma with the Expression oferbB-2 and bcl-2 Oncogenes |
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| Luo Liangping,Zhang Haiwei,Chen Jingcheng,Wang Huihua.Preliminary Studies on Correlation of Image Characteristicsof Lung Carcinoma with the Expression oferbB-2 and bcl-2 Oncogenes[J].Journal of Jinan University(Natural Science & Medicine Edition),1996(4). |
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| Authors: | Luo Liangping Zhang Haiwei Chen Jingcheng Wang Huihua |
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| Institution: | Luo Liangping 1) Zhang Haiwei 2) Chen Jingcheng 1) Wang Huihua 2) |
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| Abstract: | To explore the molecular basis of image characteristics of lung carcinoma. Immunohistochemical technique was used in combination with a computer assisted TV-image analysis system, to meas-ure the expression level of erbB-2 and bcl-2 in 33 cases of lung carcinoma which were identi-fied pathologically. The expression of erbB-2 and bcl-2 in lung carcinoma and its correlation to image characteristics were analysed. The results showed that some image manifestations of lung carcinoma such as the size of mass, invasion of tertiary bronchi and pleurae, and lymphatic metastasis of hila or mediastinum were closely related to the expression of erbB-2 and bel-2. Furthermore, a mutually restrictive effect of the expression of erbB-2 and bcl-2 oncogenes on image manifestations was shown. |
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| Keywords: | lung carcinoma immunohistochemistry erbB-2 bcl-2 radiography CT |
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