| 3,5-双三氟甲基苯甲酰氯的合成 |
| |
| 引用本文： | 王耀翔,李菊清,周孝瑞.3,5-双三氟甲基苯甲酰氯的合成[J].浙江科技学院学报,2006,18(3):189-191. |
| |
| 作者姓名： | 王耀翔 李菊清 周孝瑞 |
| |
| 作者单位： | 浙江科技学院,生物与化学工程学院,杭州,310023 |
| |
| 摘 要： | 介绍了以间双三氟甲基苯为起始原料合成3,5-双三氟甲基苯甲酰氯的方法。该合成路线经溴代、羧基化和酰化等三步反应,以61.7%的总收率得到目的物。讨论了浓硫酸用量、反应温度对溴代反应的影响,酰化温度、二甲亚砜用量对3,5-双(三氟甲基)苯甲酰氯收率的影响;得到了合成3,5-双三氟甲基苯甲酰氯的适宜条件。结果表明,该法工艺路线简单,是经济价值较高的合成路线。
|
| 关 键 词： | 3 5-双三氟甲基苯甲酰氯 间双三氟基苯 二溴海因(DBDMH) 格氏反应 |
| 文章编号： | 1671-8798(2006)03-0189-03 |
| 收稿时间： | 05 8 2006 12:00AM |
| 修稿时间： | 2006年5月8日 |
Synthesis of 3,5-Bis(Trifluoromethyl)Benzoyl Chloride |
| |
| WANG Yao-xiang,LI Ju-qing,ZHOU Xiao-rui.Synthesis of 3,5-Bis(Trifluoromethyl)Benzoyl Chloride[J].Journal of Zhejiang University of Science and Technology,2006,18(3):189-191. |
| |
| Authors: | WANG Yao-xiang LI Ju-qing ZHOU Xiao-rui |
| |
| Institution: | School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China |
| |
| Abstract: | 3,5-bis(trifluoromethyl)benzoyl chloride,as an important drug intermediate,was synthesized by 1,3-bis(trifluoromethyl)benzene with the total yield of 61.7% in three steps including bromination,carboxylation and chlorination.The effects of the amount of sulfuric acid used and the reaction temperature on bromination were discussed.The effects of the amount of dimethyl sulfoxide used and the reaction temperature on chlorination were also investigated.The suitable condition for synthesizing 3,5-bis(trifluoromethyl)benzoyl chloride was obtained.The results show that this simple technique had many advantages such as higher economic value. |
| |
| Keywords: | 3 5-bis(trifluoromethyl)benzoyl chloride 1 3-bis(trifluoromethyl)benzene 1 3-dibromo-5 5-dimethyl hydantoin(DBDMH) Grignard reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
