The SARS-CoV S glycoprotein |
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Authors: | X Xiao D S Dimitrov |
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Institution: | Protein Interactions Group, LECB, CCR, NCI-Frederick, NIH, Building 469, Room 105, Frederick, Maryland 21702-1201, USA. |
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Abstract: | The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. Recent rapid advances in our knowledge of the structure and function of this protein have lead to the development of a number of candidate vaccine immunogens and SARS-CoV entry inhibitors. |
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