| 姐妹染色单体交换检测的临床应用 |
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| 引用本文： | 马志敏,袁芝琼.姐妹染色单体交换检测的临床应用[J].大理学院学报,2007,6(6):55-57. |
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| 作者姓名： | 马志敏 袁芝琼 |
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| 作者单位： | 大理学院公共卫生学院,云南大理,671000 |
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| 摘 要： | 目的:了解在肿瘤细胞中、一些药物、致畸物引起的突变细胞中姐妹染色单体交换(SCE)率的变化.方法:查阅近几年来有关文献资料,了解SCE率改变情况.结果:肿瘤细胞及突变细胞中SCE率与正常组相比较均有显著性差异.结论:姐妹染色单体交换作为一种简便而又敏感的遗传学指标,可以快速筛选致突变物、致癌物,在毒理、临床、环境诱变和肿瘤研究等领域中的应用十分广泛.
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| 关 键 词： | 姐妹染色单体交换 检测 诱变物 |
| 文章编号： | 1672-2345（2007）06-0055-03 |
| 修稿时间： | 2007-03-23 |
Clinical application of sister chromatid exchanges |
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| MA Zhi-min,YUAN Zhi-qiong.Clinical application of sister chromatid exchanges[J].Journal of Dali University,2007,6(6):55-57. |
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| Authors: | MA Zhi-min YUAN Zhi-qiong |
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| Institution: | Faculty of Public Health, Dali University, Dali, Yunnan671000, China |
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| Abstract: | Objective: To study the changes of sister chromatid exchange(SCE) rate in the mutator cell of tumor cell and mutagenized by drug or teratogen.Methods: To review the documents and summarize the changes of SCE rate.Results: The SCE rate all had significant differences in contrast with normal groups.Conclusion: SEC rate could cull teratogen and carcinogen speedily as a simple and convenient and sensitive index of genetics.It could be applied widely to domain as toxicology,clinical medicine,environment mutagenicity,tumor research and so on. |
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| Keywords: | sister chromatid exchange checking teratogen |
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