Ribonucleaseaktivität isolierter Nebennierenmarkgranula |
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Authors: | A Philippu H J Schümann |
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Institution: | (1) Pharmakologisches Institut der Universität Frankfurt am Main, Deutschland |
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Abstract: | Summary Homogenates from suprarenal medulla of cattle were fractionated by density gradient centrifugation. The catecholamine and RNA content of all fractions obtained, as well as their RN-ase activity, were determined and expressed as % per mg protein. The chromaffin granules contain 49.8% of the catecholamines, 15.7% of the RNA, and 18.7% of the RN-ase activity of all fractions. The demonstration of RN-ase activity in the chromaffin granules is in favour of the hypothesis that this enzyme could catalyse the spontaneous release of RNA, catecholamines, and ATP at 37°C.
Ausgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft. |
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