| 干细胞动员在缺血性疾病中的应用 |
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| 引用本文： | 陈海旭,李艳华,裴雪涛. 干细胞动员在缺血性疾病中的应用[J]. 中国基础科学, 2012, 14(2): 3-8 |
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| 作者姓名： | 陈海旭 李艳华 裴雪涛 |
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| 作者单位： | 军事医学科学院野战输血研究所全军干细胞与再生医学研究室,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划,2011AA020109);国家重大科学研究计划(No:2011CB964804;2010CB945500) |
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| 摘 要： | 缺血性疾病是临床上一种严重危害健康,降低患者生活质量,致死、致残率高的疾病,主要包括肢体缺血、糖尿病坏疽、缺血性心肌梗塞及缺血性脑梗塞等。骨髓干细胞(bone marrow-derived stem cells,BMSCs)具有多向分化潜能,已成为缺血性疾病领域的研究热点,通过应用干细胞动员剂动员骨髓干细胞至缺血损伤组织诱使血管新生,改善血流灌注和氧供,修复损伤组织,为缺血性疾病的再血管化治疗提供了新策略。骨髓干细胞动员具有操作简便、安全有效、无创伤以及避免干细胞移植引起的免疫排斥反应的特点,应用骨髓干细胞动员的方法和干预策略具有较好的发展潜力。
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| 关 键 词： | 骨髓干细胞 干细胞动员 SDF-1α／CxCR4轴缺血性疾病 |
Stem Cell Mobilization in the Treatment of Ischemic Disease |
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| Chen Haixu , Li Yanhua , Pei Xuetao. Stem Cell Mobilization in the Treatment of Ischemic Disease[J]. China Basic Science, 2012, 14(2): 3-8 |
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| Authors: | Chen Haixu Li Yanhua Pei Xuetao |
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| Affiliation: | Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing 100850 |
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| Abstract: | Bone marrow-derived stem cells (BMSCs) are adult stem cells with capacity for self-renewal and multi-lineage differentiation. Studies in animal models of ischemic disease have demonstrated the ability of transplanted BMSCs to engraft and differentiate into cardiomyocytes and vascular cells. It is now well established that therapeutic angiogenesis can be achieved in animal models of hind limb and myocardial ischemia by exogenously adding angiogenic growth factors or autologously mobilize BMSCs to repair ischemic tissue. Mobilization of BMSCs to ischemic tissue for regeneration and repair is emerging as an extremely promising therapeutic agent for ischemic disease. |
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| Keywords: | bone marrow stem cells stem cell mobilization SDF-1α/CXCR4 axis ischemic disease |
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