术中支气管动脉与肺动脉灌注化疗对预防肺癌术后复发、转移的对比研究

目的 选择更有效的灌注方法，为肺癌的综合治疗提供新的治疗途径。方法 通过术中支气管动脉与肺动脉分别灌注5－氟尿嘧啶（5－FU），其靶器官中5－FU的质量浓度，标本用高效液相层析仪检测（HPLG）。结果 5－FU在支气管动脉灌注组的质量浓度明显高于肺动脉组，有显著的统计学意义（P＜0．001），血浆中的5－FU的质量浓度甚微。结论 术中支气管动脉灌注化疗可使靶器官含有较高的药物浓度，且全身毒副作用明显小于肺动脉灌注组。

The Effect of Chemotherapy Via Pulmonary and Bronchial Artery Infusion during the Operation on the Prevention of Recurrence and Metastasis of Lung Cancer after Operations

Objective Comparing for the better infusion route and the new way to treatment of lung cancer. Methods After the infusion of 5 FU through pulmonary and bronchial artery in dog,we measured the cotent of 5 FU in main bronchus,hilar lymph nodes,lung tissue and plasma.Results The mass concentration of 5 FU in bronchial artery infusion group was significantly higher (P<0.01) in above tissues. Conclusion Bronchial artery infusion during the operation can result in higher drug concentration and less systemic toxicity than pulmonary infusion.