Dicer is essential for mouse development |
| |
| Authors: | Bernstein Emily Kim Sang Yong Carmell Michelle A Murchison Elizabeth P Alcorn Heather Li Mamie Z Mills Alea A Elledge Stephen J Anderson Kathryn V Hannon Gregory J |
| |
| Institution: | Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA. |
| |
| Abstract: | To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
