Behavioural effects of naloxone in rats

Summary Naloxone in rats induces a behavioural syndrome closely resembling that induced by intraliquorally injected ACTH peptides. This effect is probably due to a displacement of the ACTH peptides from other receptors (e.g. opiate receptors).Acknowledgments. The authors are indebted to Dr M. J. Ferster of Endo Laboratories (Brussels) for the kind supply of naloxone. The excellent technical assistance of Mr Gianni Montorsi is gratefully acknowledged.