搅拌式反应器内固-液两相悬浮特性的CFD模拟

制备血液净化材料蛋白A免疫吸附柱过程中,搅拌式生物反应器的优化设计与放大技术是工业开发的重要环节.该文采用标准κ蛳ε湍流模型、多重参考系法,模拟搅拌式反应器内琼脂糖凝胶溶液加入固体催化剂后,形成的固蛳液两相体系的混合和悬浮特性.分别对DT、PBTD45、PBTU45搅拌桨的固相悬浮性能进行了研究,预测了完全离底悬浮的临界转速,并与Zwietering公式进行了比较.通过数值模拟,为反应器的优化设计提供了参考依据.

CFD simulation of solid-liquid suspension characteristics in stirred tank reactor

In the preparation of the blood purification material protein A immunoadsorption, the optimization design and scale-up of the stirred tank bioreaetor arc the key links of the industrial process In this paper, standard k-ε turbulence model and multi-reference frame method are applied to simulate the mixing and suspending characteristics of solid-liquid when adding solid catalyst to sepharose solution in the stirred tank reactor. By the researches on the solid phase suspended performance of three types of impellers, which are DT, PBTD45 and PBTU45, just-suspended impeller speeds are predicted, and the results are compared with the Zwietering correlation. Through the computational fluid dynamics simulations, the reference guidance is provided to optimize bioreactor for preparing the blood purification material.