Elimination and metabolism of dimethylnitrosamine (DMN) byXenopus laevis and other amphibians |
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| Authors: | R R Rao R H Clothier R M Hodgson M Balls |
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| Institution: | (1) Department of Human Morphology, University of Nottingham, Queen's Medical Centre, NG7 2UH Nottingham, (England);(2) Present address: Department of Biochemistry, University of Liverpool, Liverpool, (England) |
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| Abstract: | Summary The elimination of (14C)-DMN after i.p. injection intoXenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver fromXenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism byXenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic inXenopus.This work was supported by a grant from the Cancer Research Campaign. We are also grateful to Dr P. F. Swann, both for the supply of DMN and DEN and for many useful discussions. |
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