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Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle
Authors:H. Nawrath  J. Rupp  H. Jakob  U. Sack  F. Mertzlufft  W. Dick
Affiliation:(1) Pharmakologisches Institut, Universität Mainz, Obere Zahlbacher-Strasse 67, D-6500 Mainz, (Federal Republic of Germany);(2) Klinik für Anästhesiologie, Universität Mainz, D-6500 Mainz, (Federal Republic of Germany)
Abstract:Summary The opioid agonists morphine (selective for mgr-receptors) and ethylketocyclazocine (selective for kappa-receptors), at concentrations evoking strong effects in neuronal structures, did not significantly affect the configuration of the intracellularly recorded action potential and the force of contraction in ventricular heart muscle isolated from guinea pigs, rabbits and man. These results suggest that any changes of heart functions in vivo in response to opioid-like drugs are probably not mediated postsynaptically at the myocardial cell membrane but rather presynaptically, influencing the release of noradrenaline and/or acetylcholine from the nerve terminals.
Keywords:Heart muscle  opioids  morphine  ethylketocyclazocine  cardiac function  presynaptic modification
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