| 急性脑缺血家兔针刺前后环核苷酸及血管紧张素Ⅱ研究 |
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| 引用本文： | 扬军,吴有胜,许立天,李汉先.急性脑缺血家兔针刺前后环核苷酸及血管紧张素Ⅱ研究[J].江汉大学学报(自然科学版),1994(2). |
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| 作者姓名： | 扬军 吴有胜 许立天 李汉先 |
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| 作者单位： | 武汉职工医学院附属医院核医学科(扬军，吴有胜，许立天)，武汉职工医学院生理学教研室(李汉先) |
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| 摘 要： | 28只大耳白兔随机分成对照组(8只),急性脑缺血组(8只)和针刺组(12只)。夹闭兔两侧颈总动脉使颅内血压急剧下降,制造急性脑缺血动物模型。分别测定正常,夹闭时和针刺“人中”穴后家兔脑及血浆中cAMP、cGMP和AⅡ含量。结果发现:急性脑缺血时,cAMP、cGMP浓度和cAMP/cGMP比值下降,脑中AⅡ浓度下降而血浆AⅡ浓度升高。针刺“人中”后。可明显升高脑及血浆cAMP和AⅡ水平,为临床针刺治疗脑血管意外疾病提供了科学依据。
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| 关 键 词： | 急性脑缺血 针刺 环核苷酸 血管紧张素Ⅱ |
A Study on Cyclic nuqeotide and Angiotesini arund Electroacupuncture wish Rabbit of Acute Brain Ischemia |
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| Abstract: | Twenty-eight rabbits were divided into 3 groups at random,wit-h 8 control, 8 acute crain ischemia and 12 electroacupuncture. In order to reduce rabbit blood pressure in the brain quickly and creat an animal model of acute brain ischemia arteria carotis communis on both side got clipped.The concentration of cAMP, cGMP and A Ⅱ in the b-rain and plasma were detected at control, acute brain ischemia and lien zhong' Point acupnnctured. The result showed that the concentratton of cAMP, cGMP and the ratio of cAMP/cGMP reduced and the concentration of A fⅡ in the brain reduced but in the plasma increased at acute brain ischemla. That A Ⅱ and cAMP were significantly increased in the brain and plasma after electroacupuncture provided a sien-tific basis for treating brain vessel emergency with acupuncture in clinical. |
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