Die vasomotorische Wirkung von Heparin bei Normalen und bei an Raynaudscher Krankheit leidenden Patienten

Summary In 3 female patients withRaynaud's disease affecting the upper extremities, the skin temperature and plethysmographic measurements of the fingers were taken before and after thei.v. injection of 250 mg heparin (Liquemin Roche). The vasomotor effect thus observed was expressed by increase in skin temperature, pulse frequency and arterial supply, and also by decrease in duration and severity of experimentally induced ischemic attacks. After prolonged treatment with 250 mg heparini.v. daily, the skin temperature increased and the attacks decreased in frequency, duration and severity.These favorable results in functional arterial disorders are attributed to the established vasodilating action of heparin.