Influence of hydrochlorothiazide on the pain threshold and on the antinociceptive activity of morphine,in rats |
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| Authors: | R. Poggioli A. V. Vergoni A. Bertolini |
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| Affiliation: | (1) Institute of Pharmacology, University of Modena, Via G. Campi 287, I-41100 Modena, (Italy) |
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| Abstract: | Summary Hydrochlorothiazide, acutely injected in rats, has a weak analgesic activity per se and potentiates and prolongs the antinociceptive effect of morphine.This work was supported in part by grants from Consiglio Nazionale delle Ricerche, and by Ministero della Pubblica Istruzione, Roma. |
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| Keywords: | Rat hydrochlorothiazide pain threshold antinociceptive activity analgesic activity morphine |
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