Enantioselective Rh-catalyzed hydrogenation of N-acyl dehydroamino esters and enamides with monodentate phosphoramidite ligands |
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Authors: | Xinsheng Li Qianchang Ding Liangchao Li Dongcheng Xu |
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Institution: | (1) College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321004, Zhejiang, China |
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Abstract: | Chiral monodentate phosphoramidite ligands were conveniently prepared from 1,1′-bi-2-naphthol (BINOL) and (S)-pyrrolidine in good yields, which were effective chiral ligands in the enantioselective rhodium-catalyzed hydrogenation
of dehydroamino esters and enamides at low hydrogenation pressure. High conversion rate (up to 99% for dehydroamino esters
and enamides) and good enantioselectivity (up to 96.3% ee for dehydroamino esters and 91.7% ee for enamides) were obtained.
Biography: LI Xinsheng (1970–), male, Associate professor, Ph. D., research direction: asymmetric synthesis. |
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Keywords: | phosphoramidite chirality hydrogenation dehydroamino ester enamide |
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