| A template of rat brain based on fMRI T_2~* imaging |
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| 引用本文： | HU Zhenghui1,WU Yigen2,WANG Xiaochuan3,WANG Jianzhi3,CHEN Feiyan1 and TANG Xiaowei1*(1. Department of Physics and Bio-X Laboratory,Zhejiang University,Hangzhou 310027,China, 2. Institute of High Energy Physics and Key Laboratory of Nuclear Analysis Techniques,Chinese Academy of Sciences,Beijing 100039,China, 3. Department of Pathophysiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China). A template of rat brain based on fMRI T_2~* imaging[J]. 自然科学进展(英文版), 2005, 15(6). DOI: 10.1080/10020070512331342470 |
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| 作者姓名： | HU Zhenghui1 WU Yigen2 WANG Xiaochuan3 WANG Jianzhi3 CHEN Feiyan1 and TANG Xiaowei1*(1. Department of Physics and Bio-X Laboratory Zhejiang University Hangzhou 310027 China 2. Institute of High Energy Physics and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of Sciences Beijing 100039 China 3. Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China) |
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| 作者单位： | 1. Department of Physics and Bio-X Laboratory，Zhejiang University，Hangzhou 310027，China; 2. Institute of High Energy Physics and Key Laboratory of Nuclear Analysis Techniques，Chinese Academy of Sciences，Beijing 100039，China; 3. Department of Pathophysiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China |
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| 基金项目： | SupportedbytheMajorStateBasicResearchDevelopmentProgramofChina(GrantNo.19990504000) |
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| 摘 要： | Thedevelopmentofnoninvasivefunctionalneu roimagingmethodshasmadeitpossibletoinvestigatelarge scaleactivationpatternsofbrain.FMRI,arep resentativeinhemodynamictechniques,hasbeen usedextensivelyinthestudiesofthephysiology,pathologyandpsychologyofbrains[1—3],foritslessinvasiveproperty,superiorresolution,andlowercost comparedtoPETtechniques.Itisimportanttopointoutthatcommonimage analysissoftwaressuchasstatisticalparametricmap ping(SPM),analysesoffunctionalneuroimages(AFNI),createdatabydoinga…
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A template of rat brain based on fMRI T2* imaging |
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| HU Zhenghui,WU Yigen,Wang Xiaochuan,Wang jianzhi,CHEN Feiyan,Tang Xiaowei. A template of rat brain based on fMRI T2* imaging[J]. Progress in Natural Science, 2005, 15(6). DOI: 10.1080/10020070512331342470 |
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| Authors: | HU Zhenghui WU Yigen Wang Xiaochuan Wang jianzhi CHEN Feiyan Tang Xiaowei |
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| Abstract: | The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results processed with statistical parametric mapping (SPM99) software are in agreement with the results from immunohistochemical experiment, which proves that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies. |
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| Keywords: | fMRI animal model atlas template normalization T*__2. |
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