The cellular functions of clathrin |
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Authors: | S J Royle |
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Institution: | (1) MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom |
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Abstract: | Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from
donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like
coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent
advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin
lattice and discovery of a new function for clathrin that occurs during mitosis.
Received 12 December 2005; received after revision 21 March 2006; accepted 29 March 2006 |
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Keywords: | Adaptor cancer clathrin dynamin endocytosis mitosis TIRFM |
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